House and Cuddy are exploring the ramifications of their declared feelings and attempting to make a real relationship work. Meanwhile, due to a colleague's illness, Princeton Plainsboro is left without a neurosurgeon on site, threatening the hospital's accreditation as a Level 1 Trauma Center. As the team attempts treatment to get their sick colleague back to work, they discover there is more to the illness than they originally suspected and turn to House for direction. Instead, House remains elusive, leaving the team on its own.

A family copes with a sick daughter and a dying son, and the team must diagnose the daughter before it's too late. Meanwhile, House deals with an elderly father and son, and tries to deal with the challenges of a workplace romance.

When Alice, the author of a popular children's book series, inexplicably suffers from a seizure moments before an attempt to take her own life, the Princeton Plansboro team faces the challenges of evaluating both her underlying medical conditions, as well as her unstable psychological state. Unable to diagnose Alice, House becomes particularly motivated, as he's a fan of her books, and is convinced that the key to unlocking the mysteries of Alice's condition lies in the pages of her most recent novel. Meanwhile, House takes Cuddy on a double date with Wilson and his girlfriend, Sam, and makes a discovery that proves that life imitates art as the couple continues to make compromises in order to make their relationship work.

When a patient named Margaret McPherson is admitted to Princeton Plainsboro after suffering severe and uncontrollable vomiting, House and the team make unexpected discoveries about her identity as they assess her symptoms. When the symptoms don't improve, the team looks to the patient's medical history to unearth more about her past. Meanwhile, House gives Chase's new hire a cold welcome, and a visit from House's massage therapist forces House and Cuddy to confront the reservations in their relationship.

A newborn baby, Kayla, suffers from liver failure and the team discovers that her mother Abbey's blood provides a temporary cure. While they try to identify the underlying cause, House and Wilson end up babysitting Cuddy's daughter, Rachel, and realize that parenthood isn't all it's cracked p to be.

In the midst of a tight senatorial re-election race, the New Jersey incumbent's campaign manager mysteriously falls ill with liver failure and temporary paralysis. After a surprising campaign announcement is made by the incumbent, House and the team look to the candidate to find clues about the patient's condition. Meanwhile, Foreman learns that Taub has a past connection to Masters, and in an effort to save his patient's life, House must make a critical decision that may compromise his relationship with Cuddy.

A young girl on a dive brings up a jar from a sunken slave ship and breaks it, infecting herself with what appears to be smallpox. When House and his team confirm her illness, they call in the CDC, which puts the hospital under quarantine. However, House soon realizes that the girl has something else... but the only way to confirm his diagnosis is to expose himself to the disease. Meanwhile, Wilson and his ex-wife Sam try to tend to a young girl awaiting chemotherapy whose mother is trapped outside by the quarantine.

Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. Meanwhile, Taub questions his wife, Rachel, about her relationship with an infidelity support group member, and the team attends a co-worker's wedding where Wilson's relationship with Sam takes an unexpected turn.

A subway hero collapses after saving a woman, and is brought to the hospital. House dismisses heroism as stupidity, but is unable to determine the man's illness. Meanwhile, Cuddy's mother comes to see her daughter and her new boyfriend, and Taub discovers that a new billboard with his face has aroused his wife's libido.

House and the team try to link symptoms of a teenage military recruit and his drill sergeant; House secretly helps Cuddy's daughter get into a prestigious preschool; someone posted a disparaging photo of Chase on a social-networking site.

Cuddy's mother, Arlene, is admitted to Princeton Plansboro after complaining about unusual symptoms, but stubborn Arlene insists that House be removed from the case, forcing House to come up with non-conventional - and illegal - means to treat his patient. House instructs his team to follow his lead, and they discover details in Arlene's personal life that she kept secret from Cuddy and her sister Lucinda. Meanwhile, Taub's ex-wife, Rachel, puts him in contact with her brother who hires Taub to work a job on the side in exchange for much-needed income, which winds up taking a physical and emotional toll on him. Later, Cuddy places her trust in House to ensure that her mother receives the proper medical treatment, leading "by the book" medical student Masters to reevaluate her responsibility to practice within a code of ethics and to follow her boss' orders.

When a waitress with a perfect memory suffers temporary paralysis, her older sister visits her in the hospital, which triggers high stress levels and even more health complications. The patient's sharp memory proves detrimental when a grudge she's been holding against her sibling gets in the way of receiving proper medical treatment, and Masters discovers that patching a broken sisterhood may prove to be more complex than diagnosing the patient. Meanwhile, Foreman volunteers to help Taub prepare for a medical examination, and House, determined to help Wilson get back in the dating scene, discovers Wilson's secret new companion.

House participates in a school's Career Day and breaks a few rules by sharing explicit medical stories. Waiting outside the principal's office, he meets two fifth-grade students who assess House's relationship woes and try to help him understand how his selfish antics get in the way of showing Cuddy how he really feels.

A former real estate agent loses his job in the recession and conceals it from his wife, secretly taking a job as a janitor to make ends meet. He suffers from a high fever and swollen joints, and the team tries to determine which job caused his symptoms. Meanwhile, House tries to make a charity gala in Cuddy's honor "fun," Masters and Chase argue over honesty with one's spouse, and Taub and Foreman adjust to being roommates.

Tension reaches new heights when Cuddy faces sobering news that propels her to reevaluate her priorities. While House is distracted by his concern for Cuddy's well-being, the team treats a teenage patient whose worsening symptoms and suspicious body scars indicate more than just physical illness. Sensing the teen's troubled emotional and mental state, Taub turns to the patient's personal life for clues and uncovers disturbing home videos that could put the lives of his peers in danger. Meanwhile, Cuddy remains hopeful that House will be fully present when she needs him most, and a series of dreams, including a musical scene choreographed by Mia Michaels, provide glimpses into her life and her relationship with House.

A champion bull rider is attacked by a bull, but when he's taken to the hospital, it's clear that there is a deeper underlying medical problem. The team tries to diagnose without House's presence, since he's gone to a hotel to get over his breakup with Cuddy by hiring in a parade of hookers. As the patient's symptoms grow worse, the team wonders if House's judgment is impaired as he proposes progressively more dangerous diagnostic techniques.

A 23-year-old homeless man is admitted to the hospital with a skewed sense of smell, which soon turns into gastrointestinal bleeding. The man refuses to tell the team anything, making it difficult to diagnose him. Meanwhile, in the aftermath of his breakup with Cuddy, House decides to marry a much younger woman to help her get a green card... or so he claims.

Thirteen has been in prison for the past year, but the real mystery for House is what she did to get there. When she exits the prison, she is taken aback to find him waiting for her, and unaware he's got plans for the two of them for the next few days. As House probes Thirteen for more information about her crime, intent on solving the puzzle of her mysterious incarceration, they travel to an annual spud-gun competition and join forces to compete against House's much younger, overconfident rival, and along the journey uncover secrets and truths about each other. At the hospital, the team treats a science teacher suffering from severe respiratory illness, and when the team inspects the patient's house for clues to his illness, they immediately learn he's a hoarder. But upon a second visit to obtain more information, they uncover something in the many piles that shocks them. Also, Taub tries to get back into the dating scene, but winds up retreating to his old habits.

In the nineteenth episode of season seven (s7e19) of TV show House, a young girl comes up for treatment after she collapses. She was about to travel around the globe by the seas and was to set the record for being the youngest person to do so. Now her parents urge the doctors to treat her in time so that she can set to sail.

In the twentieth episode of season seven (s7e20) of TV show House, a case comes up to the hospital in which a lottery winner suffers partial paralysis. The doctors must find out the reason for his illness. Meanwhile, Cuddys mother is angry over the malpractices in the hospital and she threatens to sue the doctors, putting the careers of Cuddy and House in danger.

When House and Wilson bet on a boxing match and disagree over the outcome, Wilson gives him exactly one day to pay up or prove him wrong. House presses the boxer for more information to help prove his case and ends up attempting to breathe new life into the losing fighter's career. Meanwhile, the team begins to suspect House may have another type of drug problem.

Thirteen's friend and former ex-con arrives at Thirteen's apartment unannounced and in need of urgent medical attention. When she finds out that her friend has relapsed into drug use, Thirteen promises not to take her to the hospital where the cops could find her and instead turns to Chase in desperation. Meanwhile, House deals with devastating information, and Taub begins to come to terms with surprising news.

Well-known performance artist Afsoun Hamidi is admitted to the hospital, but when the team learns that her symptoms may have been self-inflicted as part of a documentary for her latest performance piece, they begin to question whether treatments are necessary and if they are unwittingly participating in the creation of a piece of her art. Meanwhile, a situation prompts House to do something very unexpected, a move that could change his relationship with Cuddy and Wilson permanently.