After Wilson threatens to resign House thinks of anything to try and keep him at the hospital, and to keep their friendship alive. Meanwhile, the team treat an executive assistant with a Class A personality who reminds Thirteen of herself.

The team deals with an organ donors whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.

House and his team diagnose a struggling artist dying of an unknown disease, whose illness affects not only his career and his relationship, but his work.

House's friends and teammates coerce him going into his father's funeral. However, en route they get the case of a young Chinese girl and House must participate in the differential by phone... until he's unable to take a call at a critical moment.

Thirteen's female lover has a seizure after a night of partying and she takes the woman to the hospital. It turns out the woman has a long-standing medical condition and slept with Thirteen to get House to see her. Meanwhile, Foreman confronts Thirteen about her destructive lifestyle and House continues to have Lucas spy on Wilson.

A middle-aged man finds himself suffering from blackouts and sleepwalking, and is admitted to the hospital. As his condition deteriorates, his daughter needs to transplant a kidney. Meanwhile, Cuddy prepares to adopt a baby but the mother's prior drug use damages the baby's lungs, forcing Cuddy to choose between delivering the baby early and endangering the child, or waiting and putting the birth mother's life at risk.

Due to her previous experience, Cameron works with the team to treat a agoraphobic man who refuses to leave his home. As the man's condition worsens and they have to figure a way to operate at home or relocate him to the hospital, House suffers from a maddening itch he can't identify. Meanwhile, Chase and Cameron deal with an issue in their relationship.

An emancipated 16-year-old factory worker falls ill to the point of near unexplained death. Meanwhile, Foreman tries to handle his own caseload and the diagnosis of a child without House’s oversight.

A man seeking the right diagnosis for his illness is willing to take on the hospital and the SWAT team to get it. He takes Thirteen, a nurse, and several patients from the waiting room and puts them in Cuddy’s office. To put an end to the crisis they must come up with the right diagnosis, treat the wounded, and hold off a SWAT team.

House and the team try to help a fitness guru who collapsed during an infomercial filming. Foreman conducts drug trials for Huntington's and Thirteen participates: Cuddy moves into House's office while her's is repaired, and Kutner runs an Internet advice clinic using House's name.

House and the team diagnose a bullied girl who collapses at her school's holiday pageant. Meanwhile, House gives one of his patients a gift, Cuddy gets a gift, the team tries to figure out who gave House a special gift, and Foreman learns a lesson from Thirteen during the Huntington's drug trials.

House and his team deal with a man living in constant pain. Meanwhile, Thirteen receives treatment by Foreman while taking part in his clinical trial on Huntington's Disease, and Cuddy tries to balance her hospital duties with her new baby.

House suspects a Special Education teacher of becoming ill from her inherent goodness. Meanwhile, Cameron takes on some of Cuddy’s duties and finds herself up against House. And Foreman has to make a decision when he learns that Thirteen is receiving the placebo in the Huntington’s clinical trials.

The team take on the case of a cancer researcher who gave up her career to pursue personal happiness. While House's staff question how much happiness they've found, Cuddy metes out some poetic justice to House, and Thirteen begins suffering reactions to the Huntington's trials.

A priest sees a bleeding Jesus on his doorstep and House insists on taking the case to poke fun at the man’s religion. However, when the priest displays more symptoms, the case becomes serious as he takes a turn fro the worse. Meanwhile, House gives Thirteen and Foreman an ultimatum, and Cuddy invites the staff to her baby’s christening.

Jackson, a boy born with genetic mosiacism, collapses during a basketball game. His parents don’t want the doctor to tell their son that Jackson has both male and female genes, even if that is the source of his illness. Meanwhile, Thirteen and Foreman try to hide their relationship so House won’t fire them, and House is in a surprisingly good mood.

The team takes on the case of a book editor who suffers from frontal-lobe inhibition, causing him to uncontrollably speak his mind. Meanwhile, Wilson finds his long-lost mentally ill brother and recruits Taub to help treat him.

Nursing-home worker Morgan fakes sick to get House's attention after the home, 's pet cat sleeps next to her. It seems that the cat only pays a visit to people if they are about to die , and does so with alarming accuracy. While House dismisses Morgan as a nut job, he is intrigued by her theory on the kiss-of-death cat, and sets out to disprove it. When Morgan falls seriously ill, he and the team are forced to get to the bottom of both mysteries.

House is injured in a motorcycle accident in New York, but he's more interested in the case of Lee, a man who had a bicycle accident and now appears brain-dead. House quickly determines that Lee can still think and has him transferred to Princeton to find a cure. Meanwhile, Wilson is intrigued by why House was in New York in the first place.

Charlotte is tending to her dying husband Eddie when she goes into respiratory distress. At the hospital, Eddie seems to recover while Charlotte gets worse. However, the team's attention is divided when an unexpected tragedy strikes the members from within.

When Cameron learns of an environmentalist who collapsed during a protest, she postpones her vacation with Chase to refer the case to House and stays on to make sure her former boss follows through. Chase begins to wonder if Cameron is in love with House. Meanwhile, Wilson goes on a mysterious health diet, piquing House's interest.

A deaf 14-year-old wrestler collapses during a wrestling match while hearing imaginary explosions. However, House is distracted by his lack of sleep, hallucinations of a familiar face, and his preparations for Chase's bachelor party.

When a ballerina's lungs collapse during a performance, she's brought to the hospital where the team soon discovers that her skin is coming off. House is distracted by his hallucinations of Amber and the realization of the only way to stop them. Meanwhile, Cameron asks Chase for a special pre-nupitial gift.

A patient, Scott, has a rebellious left hand when the left and right sides of his brains start acting independently. Meanwhile, House deals with the aftermath of his one-night stand with Cuddy.